At single oral doses of a hundred mg and 200 mg, transient dose-associated impairment of coloration discrimination was detected using the Farnsworth-Munsell 100-hue take a look at, with peak results close to the time of peak plasma amounts. This finding is according to the inhibition of PDE6, that's involved in phototransduction while in the retina

{???, ?????? ?????????????? ????????? ?????????????? ??????????? ?????? ??????????? ?????? ????????????? ??? ??? ????????????? ????????????????????? ??? ???...?????????????????????????????????????????? ?????????????? ?????????? ????? ??????? ????? ???????? ????? ?????? ??? ???????????????????????????????????????????????. ??? ????????? ????? ???? ??